Recently, the team of Cheng Guosheng of the Institute of Nanotechnology, Chinese Academy of Sciences and the team of Dai Jianwu of the Institute of Genetics and Development of the Chinese Academy of Sciences have successfully developed a new graphene three-dimensional neural scaffold material and systematically studied the interaction between graphene scaffolds and neural stem cells. Related research was published in the "Science Report", a sub-journal of "Nature".

According to reports, graphene is a low-dimensional carbon nanomaterial composed of a single layer or few layers of carbon atoms. It has excellent physical and chemical properties. Since its discovery in 2004, it has rapidly become a research object in the fields of materials science and condensed matter physics. At the same time, graphene can show good biocompatibility, and has been used in cell imaging, drug delivery, stem cell engineering, and tumor treatment.

Previously, the team of Cheng Guosheng has systematically studied the effect of two-dimensional graphene films on the development of hippocampal neuronal cells, and found that graphene not only has good biocompatibility for nerve cells, but also has a significant role in promoting neurite outgrowth and growth. The team also carried out functional modification of the bioactive molecules on the graphene surface, and quantitatively analyzed the effect of the adsorption of active molecules on the interaction of graphene sheets.

Subsequently, the research team further developed a new graphene foam material used as a scaffold for neural stem cells based on the research work on the three-dimensional porous carbon material reported by the research group of the Institute of Shenyang Metals, Chinese Academy of Sciences.

Studies have shown that three-dimensional graphene scaffolds can not only promote the proliferation of neural stem cells, but also induce the differentiation of neural stem cells into functional neurons to a certain extent. Researchers further used the good electrical conductivity of graphene carbon materials to in situ electrical stimulation and differentiation of neural stem cells, and successfully obtained a reversible calcium ion oscillation response.

Experts said that in view of the excellent characteristics of the three-dimensional graphene structure, it is expected to be used in the fields of neural tissue engineering and neural stem cell transplantation therapy.

At present, the team is further conducting research on neuronal synapse formation, neural signal transmission, and repair of damaged nerve cells on three-dimensional graphene scaffolds at both in vitro and in vivo levels.

The research was supported by the “973” project of the Ministry of Science and Technology, the Pilot Project of Stem Cells and Regenerative Medicine of the Chinese Academy of Sciences, and the International Cooperation Project of the National Natural Science Foundation of China.

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